Genetic Composition of Supercritical Branching Populations under Power Law Mutation Rates / Vianney Brouard    

Public ISBD Faire une suggestion d'achat Titre : Genetic Composition of Supercritical Branching Populations under Power Law Mutation Rates Type de document : document électronique Auteurs : Vianney Brouard, Auteur Editeur : arXiv Année de publication : 2023 Langues : Anglais (eng) Catégories : 576 Évolution, génétique:576.01 Philosophie et théorie de la génétique et de l'évolution Tags : 'cancer evolution  multitype branching processes  finite graph  , long time behavior  power law mutation rates  population genetics  génétique  Évolution  Populations and Evolution (q-bio.PE)'. Résumé : We aim at understanding the evolution of the genetic composition of cancer cell populations. To this aim, we consider a branching individual based model representing a cell population where cells divide, die and mutate along the edges of a finite directed graph (V,E). The process starts with only one cell of trait 0. Following typical parameter values in cancer cell populations we study the model under large population and power law mutation rates limit, in the sense that the mutation probabilities are parameterized by negative powers of n and the typical sizes of the population of our interest are positive powers of n. Under non-increasing growth rate condition (namely the growth rate of any sub-population is smaller than the growth rate of trait 0), we describe the time evolution of the first-order asymptotics of the size of each sub-population on the log(n) time scale, as well as in the random time scale at which the initial population, resp. the total population, reaches the size nt. In particular, such results allow to characterize whose mutational paths along the edges of the graph are actually contributing to the size order of the sub-populations. Without any condition on the growth rate, we describe the time evolution of the orders of magnitude of each sub-population. Adapting techniques from Durrett and Mayberry 2011, we show that these converges to positive deterministic non-decreasing piecewise linear continuous functions, whose slopes are given by an algorithm. En ligne : https://arxiv.org/abs/2309.12055 Format de la ressource électronique : PDF Genetic Composition of Supercritical Branching Populations under Power Law Mutation Rates [document électronique] / Vianney Brouard, Auteur . - arXiv, 2023. Langues : Anglais (eng) Catégories : 576 Évolution, génétique:576.01 Philosophie et théorie de la génétique et de l'évolution Tags : 'cancer evolution  multitype branching processes  finite graph  , long time behavior  power law mutation rates  population genetics  génétique  Évolution  Populations and Evolution (q-bio.PE)'. Résumé : We aim at understanding the evolution of the genetic composition of cancer cell populations. To this aim, we consider a branching individual based model representing a cell population where cells divide, die and mutate along the edges of a finite directed graph (V,E). The process starts with only one cell of trait 0. Following typical parameter values in cancer cell populations we study the model under large population and power law mutation rates limit, in the sense that the mutation probabilities are parameterized by negative powers of n and the typical sizes of the population of our interest are positive powers of n. Under non-increasing growth rate condition (namely the growth rate of any sub-population is smaller than the growth rate of trait 0), we describe the time evolution of the first-order asymptotics of the size of each sub-population on the log(n) time scale, as well as in the random time scale at which the initial population, resp. the total population, reaches the size nt. In particular, such results allow to characterize whose mutational paths along the edges of the graph are actually contributing to the size order of the sub-populations. Without any condition on the growth rate, we describe the time evolution of the orders of magnitude of each sub-population. Adapting techniques from Durrett and Mayberry 2011, we show that these converges to positive deterministic non-decreasing piecewise linear continuous functions, whose slopes are given by an algorithm. En ligne : https://arxiv.org/abs/2309.12055 Format de la ressource électronique : PDF

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